Originally posted by: Metron
"Deagles" are only popular because of Counter Strike, and they have no real world practicality.
Go get a
Kimber .45 TLE II which is basically the same gun carried by LAPD SWAT. Very nice custom .45 and very reliable.
Most 9mm rounds won't penetrate a car door... if you have to put your life on the line, carry a weapon with some power, like the .45.
*edit*
If you're looking primarily for home defense, get a Ruger or S&W .44 magnum revolver. Load it up with Cheney-style bird shot rounds, and you have a legal short-barreled 6 shot shotgun.