If I transfer a "program" from my C drive to my external hard drive and then remove the same from my C drive (add/remove programs) is that program still accessible for full and proper use?
Depends on the program; some install hooks in the system that will make it break if moved anywhere, including to another directory on C. Others are self-contained and don't care where they are.
If you want to install a new app on the other hard drive, Windows doesn't care whether it's internal or external.
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