Not really... Basically you just get it up and running, and assuming you've used good hardware and done a good job on assembly it should just go. A home server is just a desktop machine dedicated to that particular purpose... Of course, you'll want to select your parts with that purpose in mind - plenty of RAM and a fast hard drive, for example...
I built myself a little Duron 700 box that I use as a webserver... Tossed it together, installed Win2k with minimal options, good to go. I usually log in about once a month to download patches and updates, scan for viruses, reboot if the updates require and forget about it again.
If you're so inclined, you could try running Linux for your server and maybe learn some things in the process, but I didn't want to mess with it, so Win2k for me.