I'd spray the area with a good vegetation killer...should stop anything from growing in the ground for up to 1 year. Cover the area with a good, heavy-duty weed cloth, (not the flimsy perforated black stuff) they a few inches of crushed rock for drainage and to help keep weeds from growing later. (Weed seeds can blow in to almost anywhere...and if they can get a start, will root in almost anything)
Keep in mind, your F-150 will probably only haul about 1/2 yard of dirt/rock, etc. check your weight capacity carefully.
plastic wheelbarrow? Did you get it at Toys-R-Us?