Originally posted by: Skoorb
Originally posted by: Chaotic42
Originally posted by: Skoorb
I guess you can stop eating because artificial chemicals are in almost everything you can think of consuming
True, there are lots of chemicals in processed foods. Lots of chemicals which have undergone rigorous testing. Splenda, it would seem, hasn't.
It's undergone some, so it's been passed by the FDA. I'm sure some of these other chemicals may possibly have problems that the FDA hasn't identified, and Splenda may as well, but they do a good battery of tests on these artificial sweeteners (like making a rat live off it for a while
) before clearing them.
Mouse? Then here you go:
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The comet assay with 8 mouse organs: results with 39 currently used food additives.
Sasaki YF, Kawaguchi S, Kamaya A, Ohshita M, Kabasawa K, Iwama K, Taniguchi K, Tsuda S.
Laboratory of Genotoxicity, Faculty of Chemical and Biological Engineering, Hachinohe National College of Technology, Tamonoki Uwanotai 16-1, Aomori 039-1192, Japan.
yfsasaki-c@hachinohe-ct.ac.jp
We determined the genotoxicity of 39 chemicals currently in use as food additives. They fell into six categories-dyes, color fixatives and preservatives, preservatives, antioxidants, fungicides, and sweeteners. We tested groups of four male ddY mice once orally with each additive at up to 0.5xLD(50) or the limit dose (2000mg/kg) and performed the comet assay on the glandular stomach, colon, liver, kidney, urinary bladder, lung, brain, and bone marrow 3 and 24h after treatment. Of all the additives, dyes were the most genotoxic. Amaranth, Allura Red, New Coccine, Tartrazine, Erythrosine, Phloxine, and Rose Bengal induced dose-related DNA damage in the glandular stomach, colon, and/or urinary bladder. All seven dyes induced DNA damage in the gastrointestinal organs at a low dose (10 or 100mg/kg). Among them, Amaranth, Allura Red, New Coccine, and Tartrazine induced DNA damage in the colon at close to the acceptable daily intakes (ADIs). Two antioxidants (butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT)), three fungicides (biphenyl, sodium o-phenylphenol, and thiabendazole),
and four sweeteners (sodium cyclamate, saccharin, sodium saccharin, and sucralose) also induced DNA damage in gastrointestinal organs. Based on these results, we believe that more extensive assessment of food additives in current use is warranted.
PMID: 12160896 [PubMed - indexed for MEDLINE]
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Renal mineralization--a ubiquitous lesion in chronic rat studies.
Lord GH, Newberne PM.
Mallory Institute of Pathology, Boston, MA 02118.
Renal mineralization is a commonly encountered lesion in old rats and its presence at times complicates the interpretation of data derived from chronic rat studies. The feeding of sucralose, a new and high-intensity sweetener under regulatory review, resulted in caecal enlargement and an increase in the incidences of renal mineralization and pelvic epithelial hyperplasia. These responses prompted a review of the literature focusing on the relationships, if any, between the caecal and renal changes. The literature supports the contention that caecal and renal changes occur frequently in response to feeding poorly absorbed osmotically active substances to rats. Some possible mechanisms that may be involved in the development of the renal lesion are discussed.
PMID: 2210518 [PubMed - indexed for MEDLINE]
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I found those links on Google.
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