For sound card, I'd recommend the Santa Cruz. Clean, clear, and IMHO, much better than Creative and their drives/software.
For speakers, check these out...with one warning: NOT FOR SURROUND SOUND IN GAMES UNLESS USING THE NFORCE MOBO!!!!! There's no analog inputs for the rear channels, so forget about full surround in games. However, as Carmack (DOOM III) said, it will support Dolby Digital 5.1, and he thinks ALL games will end up going that route over EAX. Then, these WOULD get surround. Anyway....nice little remote, SPDIF and OPTICAL connection, good for music and great for DVD, can attach to xbox/playstaion, DVD, or computer; and have a nice balance to all the speakers. The bass certainly can't compete with the Klipsch, but is very nicely balanced in the system. Will shake the walls, not blow them down.

Some may view that as a negative. Was so impressed with mine, ordered a third set (third because a friend bought mine from me the first night he heard them on some movies) for my parents as a gift.
Here's a link.... I posted it as a hot deal back then. See they're still discounted, so think I'll repost it again as it's been MANY months. Believe they should be $334 with shipping if ordered in States.
http://www.icuii.com/hardware/