From all of the experience that I've had with Asus boards which is 3 for myself and 6 that I've built for people , if you are wanting to overclock , this is one of the easiest boards to use. Once you get your system set up , ASUS has software that is included on some of their boards A-I Tuner....and the Bios on most of the boards are VERY easy to adjust overclock on.
I'm not for sure yet about the P5WD2-E , as that I've just ordered it , and have not actually recieved it yet. But these have all been very simple. In the bios , you can change values from 5,10,15,20,30% overclock. And the system will automatically adjust all of the values to acheive that setting. I reccomend using a utility like Motherboard Monitor 5 or the ASUS A-I tool , as they show case and processor temps. Monitor your setup at stock speeds for a while until you get used to the temps your machine runs. If you are using fan cooling for your case , play with that a bit to see if you can optimize your stock speeds temp level in both the case and the CPU. Remember , your CPU temp can never really go any lower than the Case temp that it's sitting in. So play with it a bit , just take your time.
When you are ready to overclock , do it in small steps , and monitor your temps. 99.9% of the time , the only thing too high of an overclock is going to do , is lock up your machine, when this happens , you just have to go to the bios upon reboot , and tune it down a notch. no messing with Jumpers and all that jazz.
Have fun with it , but be patient and take your time!