i'm a guy, and personally i like the andy thing. the commercials are annoying at times, and i think that is just what the company wants to do. (IMHO) if a commercial annoys the heck out of you, then it's bound to leave a lasting impression. then when it's time to order a pizza, Dominos becomes one of the options because you remember the annoying andy. that is the reason why you see so many pointless, yet funny commercials. to get consumers to remember the product and the company.
also remember when there was the Noid. not only did it help consumers remember the product, but it also spawned off its own merchandising, no matter how small it may have been. i remember seeing Noid t-shirts, stuffed animal, etc. in this internet society, anything's possible if andy ever gets popular.