It would, but, cable management will be tight. Look at the pix.
Look @ the mobo screw standoff. That's for an ATX board, measuring 12"x9.6". The AM4E measures 12"x10.6". It will cover, I think half of the space of the 2 holes where you'll have to route the 24-pin PSU power for the mobo, sata cables & I don't see where you'll route the 8-pin EPS. You're limited to 11.4" for your GPU in SLI/CF, 17.3" if you only plan to use one GPU.
Hope this helps!