I have had a serious set of troubles with this mobo / WinXP / Office 2K combination.
I updated to the latest mobo drivers and the latest detonator driver (I have a GF2 64meg card instead of the onboard on this system) and the problem with Office went away completely.
THe symptoms were when ever I would close Outlook 2K or Windows Help the system would slow to a crawl for 2 or 3 minutes.
The mouse would still move around but when you click on a desktop icon it would take about 10 seconds to change focus. Trying to switch applications would wait until the slowdown was done then all the clicks you made would all happen at once.
Installing the new detonator driver solved a problem another TeAm Anandtech member had with a program called SetiQ so I thought what the heck and installed it, and my problem with Office & Help went away completely!
Now if I could get this thing to stop hanging randomly for no apparent reason my shiny new 2400+ would be so very grateful

Anybody got a link to a good 400+ Watt PSU I can get for a great price?