Denali has road access. I have driven there but I have taken the train from Anchorage to Denali as well think we stopped of at Telketna (sic?) where there was a blue grass fesitval going on.
Also took the train from DC to just past Cleveland. I would do it again epescialy out west with one of the dome cars.
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Fly. It's better in every way. If you want to take a train ride do it in another part of the world where the train is actually faster than driving or has more to see.
-For those four days, I had three choices. Go to the scenery car. Go to the informal Dining car (which was incredibly expensive) or go to the smoking car. After four days, I had a bit of cabin fever.
i did newark->DC on NYE one year because they cancelled all the flights. more spacious, power outlets, wifi, and you arent treated like a terrorist.
however its slow, and in some cases not substantially cheaper so its not a preferred method of mine