Anyone ever have elevated CPK?

[manlymatt83]

I was in the hospital with CPK levels of 1100.... they said it wasn't a big deal, that I wasn't hydrating myself properly.

Anyone ever experience this?

 

[Mermaidman]

IIRC, elevated CPK indicates muscle damage? Paging Dr ATOT!

 

[KLin]

http://www.nlm.nih.gov/medlineplus/ency/article/003503.htm

Did you have a heart attack? A stroke? Pulmonary Infarction?

 

[TraumaRN]

Originally posted by: mjuszczak
I was in the hospital with CPK levels of 1100.... they said it wasn't a big deal, that I wasn't hydrating myself properly.

Anyone ever experience this?

I'll just leave it to wikipedia since it gives a decent and easy to understand definition:

CK is often determined routinely in emergency patients. In addition, it is determined specifically in patients with chest pain and acute renal failure. Normal values are usually between 25 and 200 U/L. This test is not specific for the type of CK that is elevated.

Elevation of CK is an indication of damage to muscle. It is therefore indicative of injury, rhabdomyolysis, myocardial infarction, myositis, myocarditis, malignant hyperthermia and neuroleptic malignant syndrome. It is also seen in McLeod syndrome and hypothyroidism. The use of statin medications, which are commonly used to decrease serum cholesterol levels, may be associated with elevation of the CPK level in about 1% of the patients taking these medications, and with actual muscle damage in a much smaller proportion.

Lowered CK can be an indication of alcoholic liver disease and rheumatoid arthritis.

Isoenzyme determination has been used extensively as an indication for myocardial damage in heart attacks. Troponin measurement has largely replaced this in many hospitals, although some centres still rely on CK-MB

http://en.wikipedia.org/wiki/Creatine_kinase

Note: CK=CPK

 

[manlymatt83]

Originally posted by: DeathBUA

Originally posted by: mjuszczak
I was in the hospital with CPK levels of 1100.... they said it wasn't a big deal, that I wasn't hydrating myself properly.

Anyone ever experience this?

I'll just leave it to wikipedia since it gives a decent and easy to understand definition:

CK is often determined routinely in emergency patients. In addition, it is determined specifically in patients with chest pain and acute renal failure. Normal values are usually between 25 and 200 U/L. This test is not specific for the type of CK that is elevated.

Elevation of CK is an indication of damage to muscle. It is therefore indicative of injury, rhabdomyolysis, myocardial infarction, myositis, myocarditis, malignant hyperthermia and neuroleptic malignant syndrome. It is also seen in McLeod syndrome and hypothyroidism. The use of statin medications, which are commonly used to decrease serum cholesterol levels, may be associated with elevation of the CPK level in about 1% of the patients taking these medications, and with actual muscle damage in a much smaller proportion.

Lowered CK can be an indication of alcoholic liver disease and rheumatoid arthritis.

Isoenzyme determination has been used extensively as an indication for myocardial damage in heart attacks. Troponin measurement has largely replaced this in many hospitals, although some centres still rely on CK-MB

http://en.wikipedia.org/wiki/Creatine_kinase

Note: CK=CPK

They think I had rhabdomyolysis

 

[TraumaRN]

Originally posted by: mjuszczak

Originally posted by: DeathBUA

Originally posted by: mjuszczak
I was in the hospital with CPK levels of 1100.... they said it wasn't a big deal, that I wasn't hydrating myself properly.

Anyone ever experience this?

I'll just leave it to wikipedia since it gives a decent and easy to understand definition:

CK is often determined routinely in emergency patients. In addition, it is determined specifically in patients with chest pain and acute renal failure. Normal values are usually between 25 and 200 U/L. This test is not specific for the type of CK that is elevated.

Elevation of CK is an indication of damage to muscle. It is therefore indicative of injury, rhabdomyolysis, myocardial infarction, myositis, myocarditis, malignant hyperthermia and neuroleptic malignant syndrome. It is also seen in McLeod syndrome and hypothyroidism. The use of statin medications, which are commonly used to decrease serum cholesterol levels, may be associated with elevation of the CPK level in about 1% of the patients taking these medications, and with actual muscle damage in a much smaller proportion.

Lowered CK can be an indication of alcoholic liver disease and rheumatoid arthritis.

Isoenzyme determination has been used extensively as an indication for myocardial damage in heart attacks. Troponin measurement has largely replaced this in many hospitals, although some centres still rely on CK-MB

http://en.wikipedia.org/wiki/Creatine_kinase

Note: CK=CPK

They think I had rhabdomyolysis

One, why are u out of the hospital, and how long did you not eat to do that to yourself. Rhabdo is not something you get over the course of a day.... I mean unless u were in a car accident or surgery or some sort of trauma

 

[manlymatt83]

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: DeathBUA

Originally posted by: mjuszczak
I was in the hospital with CPK levels of 1100.... they said it wasn't a big deal, that I wasn't hydrating myself properly.

Anyone ever experience this?

I'll just leave it to wikipedia since it gives a decent and easy to understand definition:

CK is often determined routinely in emergency patients. In addition, it is determined specifically in patients with chest pain and acute renal failure. Normal values are usually between 25 and 200 U/L. This test is not specific for the type of CK that is elevated.

Elevation of CK is an indication of damage to muscle. It is therefore indicative of injury, rhabdomyolysis, myocardial infarction, myositis, myocarditis, malignant hyperthermia and neuroleptic malignant syndrome. It is also seen in McLeod syndrome and hypothyroidism. The use of statin medications, which are commonly used to decrease serum cholesterol levels, may be associated with elevation of the CPK level in about 1% of the patients taking these medications, and with actual muscle damage in a much smaller proportion.

Lowered CK can be an indication of alcoholic liver disease and rheumatoid arthritis.

Isoenzyme determination has been used extensively as an indication for myocardial damage in heart attacks. Troponin measurement has largely replaced this in many hospitals, although some centres still rely on CK-MB

http://en.wikipedia.org/wiki/Creatine_kinase

Note: CK=CPK

They think I had rhabdomyolysis

One, why are u out of the hospital, and how long did you not eat to do that to yourself. Rhabdo is not something you get over the course of a day.... I mean unless u were in a car accident or surgery or some sort of trauma

Normal CPK levels are 25-200. Mine were 1100 in the hospital, they dropped to 500, then back up to 800, and then 700, over the period of three days. They said everything else came back OK (Chest Xray, EKG, blood work, creatinine, etc.).

I started intense work out about a year ago, and they think I got tihs way because I don't hydrate myself enough while working out.

So we'll see.

 

[Mallow]

different isozymes of cpk indicate different things. If my memory serves me, CK-MB is more of a skeletal muscle damage indicator (think post working out). There is another isozyme that is more indicative of myocardial dmg... can't remember which one it is right now. My guess is if they sent you home from the ER then you're ok

 

[amol]

I came in thinking this thread was about California Pizza Kitchen

 

[herbiehancock]

Originally posted by: Mallow
different isozymes of cpk indicate different things. If my memory serves me, CK-MB is more of a skeletal muscle damage indicator (think post working out). There is another isozyme that is more indicative of myocardial dmg... can't remember which one it is right now. My guess is if they sent you home from the ER then you're ok

Unfortunately, your memory doesn't serve you at all well in this case. The MB fraction of CPK is more representative of myocardial damage.

While it's true that such things as kidney failure, chronic muscle disease, low thyroid hormone levels, alcohol abuse, and persons suffering from dyspnea (difficulty breathing) and using their chest muscles to respire can cause an elevated CK-MB level, a myocardial event is established through a ratio of CK-MB to total CK (relative index). If the relative index is .2.5-3, then myocardial damage is probable. If the relative index is below this value then skeletal muscles were damaged.

 

[manlymatt83]

Originally posted by: herbiehancock

Originally posted by: Mallow
different isozymes of cpk indicate different things. If my memory serves me, CK-MB is more of a skeletal muscle damage indicator (think post working out). There is another isozyme that is more indicative of myocardial dmg... can't remember which one it is right now. My guess is if they sent you home from the ER then you're ok

Unfortunately, your memory doesn't serve you at all well in this case. The MB fraction of CPK is more representative of myocardial damage.

While it's true that such things as kidney failure, chronic muscle disease, low thyroid hormone levels, alcohol abuse, and persons suffering from dyspnea (difficulty breathing) and using their chest muscles to respire can cause an elevated CK-MB level, a myocardial event is established through a ratio of CK-MB to total CK (relative index). If the relative index is .2.5-3, then myocardial damage is probable. If the relative index is below this value then skeletal muscles were damaged.

They did tests galore on me (blood tests) including creatinine and tropomine and a bunch of other stuff, and came up with the conclusion that this was from working out. Both hospitals came up with this conclusions (I was in two).

I assume its safe to trust their opinion since they sent me home? (both of them, although the first one admitted me for 2 days)

 

[DrPizza]

Wife (nurse) standing over my shoulder confirms herbiehancock and DeathBUA

 

[manlymatt83]

Originally posted by: DrPizza
Wife (nurse) standing over my shoulder confirms herbiehancock and DeathBUA

DrPizza:

Tell your wife my total CK ranged from 500 - 1100, and it was 700 when I left the hospital. Chest X ray, Ultrasound of the heart, as well as a crap load of blood tests (CBC, Trponine, Creatinine, Buds, and other stuff) all came back OK except for the elevated CK.

Both hospitals were convinced that the elevated levels were because of working out too much and not having enough water in my body, especially since I recently started doing heavy lifting and such.

Granted, my blood pressure and pulse were high in the hospital (150/90, and pulse up to 120), which is the original reason I went into the hospital, but both hospitals claim that they know from blood tests that this is from working out...

 

[chris7b]

CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

 

[manlymatt83]

Originally posted by: chris7b
CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

The only one that seemed to have gotten checked on mine was CK... and it ranged from 500 - 1100........

They did other tests to confirm this wasn't my heart. Are there other possibilities?

 

[TraumaRN]

Originally posted by: mjuszczak

Originally posted by: chris7b
CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

The only one that seemed to have gotten checked on mine was CK... and it ranged from 500 - 1100........

They did other tests to confirm this wasn't my heart. Are there other possibilities?

What do you mean other possibilities, you worked yourself out to the point of rhabdomyolysis, which is a potentially life threatening event.

We just check CK nowadays, we have other tests for myocardial damage(troponin I)

EDIT: If You want more info on the condition you had, I can do that for you. Much better than webmd or wiki

 

[manlymatt83]

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: chris7b
CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

The only one that seemed to have gotten checked on mine was CK... and it ranged from 500 - 1100........

They did other tests to confirm this wasn't my heart. Are there other possibilities?

What do you mean other possibilities, you worked yourself out to the point of rhabdomyolysis, which is a potentially life threatening event.

We just check CK nowadays, we have other tests for myocardial damage(troponin I)

My troponin was low... is that OK?

 

[TraumaRN]

Originally posted by: mjuszczak

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: chris7b
CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

The only one that seemed to have gotten checked on mine was CK... and it ranged from 500 - 1100........

They did other tests to confirm this wasn't my heart. Are there other possibilities?

What do you mean other possibilities, you worked yourself out to the point of rhabdomyolysis, which is a potentially life threatening event.

We just check CK nowadays, we have other tests for myocardial damage(troponin I)

My troponin was low... is that OK?

Troponin is a cardiac indicator for heart damage/ischemia/angina/heart attack. Very specific and accurate and low is normal. The result usually reads <0.02ng/ml(for a negative result, anything above 0.40 ng/ml is considered positive).

Like I said I can send u some great info from a peer reviewed site about rhabdomyolysis.

 

[manlymatt83]

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: chris7b
CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

The only one that seemed to have gotten checked on mine was CK... and it ranged from 500 - 1100........

They did other tests to confirm this wasn't my heart. Are there other possibilities?

What do you mean other possibilities, you worked yourself out to the point of rhabdomyolysis, which is a potentially life threatening event.

We just check CK nowadays, we have other tests for myocardial damage(troponin I)

My troponin was low... is that OK?

Troponin is a cardiac indicator for heart damage/ischemia/angina/heart attack. Very specific and accurate and low is normal. The result usually reads <0.02ng/ml(for a negative result, anything above 0.40 ng/ml is considered positive).

Like I said I can send u some great info from a peer reviewed site about rhabdomyolysis.

Good My troponine is low but my CPK is high, so therefore this seems like Rhabdomyolysis and they were correct. My CPK kept going up and down (it wasn't constantly going down), but it was staying below a 1000... and some reading I have done suggests that sometimes it can take up to a week to drop to normal levels. My kidneys were fine so that's what was good. I guess I just won't work out again until I get checked out again, and I guess I should visit with my doctor and get the high blood pressure issue taken care of so I can live a nice long life

 

[TraumaRN]

Originally posted by: mjuszczak

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: DeathBUA

Originally posted by: mjuszczak

Originally posted by: chris7b
CPK-BB - Brain/lung damage
CPK-MB - mycardium
CPK-MM - skeletal muscle

The only one that seemed to have gotten checked on mine was CK... and it ranged from 500 - 1100........

They did other tests to confirm this wasn't my heart. Are there other possibilities?

What do you mean other possibilities, you worked yourself out to the point of rhabdomyolysis, which is a potentially life threatening event.

We just check CK nowadays, we have other tests for myocardial damage(troponin I)

My troponin was low... is that OK?

Troponin is a cardiac indicator for heart damage/ischemia/angina/heart attack. Very specific and accurate and low is normal. The result usually reads <0.02ng/ml(for a negative result, anything above 0.40 ng/ml is considered positive).

Like I said I can send u some great info from a peer reviewed site about rhabdomyolysis.

Good My troponine is low but my CPK is high, so therefore this seems like Rhabdomyolysis and they were correct. My CPK kept going up and down (it wasn't constantly going down), but it was staying below a 1000... and some reading I have done suggests that sometimes it can take up to a week to drop to normal levels. My kidneys were fine so that's what was good. I guess I just won't work out again until I get checked out again, and I guess I should visit with my doctor and get the high blood pressure issue taken care of so I can live a nice long life

Your high blood pressure was probably a result of the muscle damage overloading your kidneys and causing your BP to go up... since being in rhabdo generally throws your body in acute renal failure.

 

[manlymatt83]

But my kidneys were fine. They sent me home yesterday, then I went back, and they sent me home again.... apparently just saying "drink a lot of fluids". Creatinine levels and BUN levels were fine.....

But yeah, I'm home now and my blood pressure is stlil a little elevated...

 

[TraumaRN]

Probably caught it early before it got serious. If it was severe you wouldn't be sitting here typing on ATOT.

 

[manlymatt83]

But I'm curious then... if my numbers were still going up/down why did they send me home? What makes them think those numbers won't just go up further, like say to 2000? Or are there other tests that they did like the 6000 blood work measurements to show that everythin gelse was OK and as long as I don't work out like crazy again like I was doing it'll be ok?

That's where I'm confused. If these numbers were high why did both hospitals send me home?

 

[TraumaRN]

Originally posted by: mjuszczak
But I'm curious then... if my numbers were still going up/down why did they send me home? What makes them think those numbers won't just go up further, like say to 2000? Or are there other tests that they did like the 6000 blood work measurements to show that everythin gelse was OK and as long as I don't work out like crazy again like I was doing it'll be ok?

That's where I'm confused. If these numbers were high why did both hospitals send me home?

Do u just want me to pm/e-mail u the article i'm reading? It'll answer all your questions

 

[TraumaRN]

And actually looking it over you probably didnt have true rhabdo, at least not to the extent that I've seen some of my patients. You had a mild form of it which is what I thought. Article just confirmed it for me.