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Anyone ever been to India without a typhoid vaccination?

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AreaCode707 said:
Mm, you're not giving me a lot of reason to put faith in your medical wisdom here. Rheumatoid arthritis is when the body's immune system attacks the connective tissue in the joints. The most effective arthritis treatments are those which regulate the immune system to reduce that activity.
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If that didn't tip you, did you further read his understanding of chemotherapy? 😀
 
Life is too short to vacation in countries like India, Kenya, Bangladesh, Pakistan, and Syria etc over places like the US, Switzerland, Canada, Netherlands, Germany, Denmark, Sweden, Australia, Fiji, many of the Caribbean Islands etc.
 
bradley said:
Life is too short to vacation in countries like India, Kenya, Bangladesh, Pakistan, and Syria etc over places like the US, Switzerland, Canada, Netherlands, Germany, Denmark, Sweden, Australia, Fiji, many of the Caribbean Islands etc.
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I believe the brevity of an individual's life is actually enough reason as to why one would want to visit the less sterile, packaged parts of the world.
 
AreaCode707 said:
Mm, you're not giving me a lot of reason to put faith in your medical wisdom here. Rheumatoid arthritis is when the body's immune system attacks the connective tissue in the joints. The most effective arthritis treatments are those which regulate the immune system to reduce that activity.
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Except Enbrel, according to Pfizer, doesn't regulate or modulate immunity (as 1,25-dihydroxy Vitamin D3 would) it supresses it, "Because ENBREL suppresses the immune system, patients are at a greater risk for getting serious infections."

Regulate
1.Control or maintain the rate or speed of (a machine or process) so that it operates properly.

Suppress
1.Forcibly put an end to.

Huge distinction.
 
bradley said:
Except Enbrel, according to Pfizer, doesn't regulate or modulate immunity (as 1,25-dihydroxy Vitamin D3 would) it supresses it, "Because ENBREL suppresses the immune system, patients are at a greater risk for getting serious infections."

Regulate
1.Control or maintain the rate or speed of (a machine or process) so that it operates properly.

Suppress
1.Forcibly put an end to.

Huge distinction.
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Enbrel doesn't "forcibly put an end to" the immune system.
 
How did you spend the Wednesday? Did you drive a car? I hope you had a good time in Bangalore. Post pics!!
 
Raghu said:
How did you spend the Wednesday? Did you drive a car? I hope you had a good time in Bangalore. Post pics!!
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HAHHAHAHAHAH! There is NO way I would drive a car here! It is super crazy.

Unfortunately there's been no time for exploring or pics. Unless you want pics of a cube farm... Haven't been anywhere but the airport to the hotel in the dark, and the hotel to the office (1 block walk). :/
 
Gibsons said:
Enbrel doesn't "forcibly put an end to" the immune system.
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Yes it does. Whether the body's natural immune response completely recovers is another story entirely.

Enbrel binds to TNF alpha (with an extremely stable 100+ hour half-life) and profoundly inhibits its action as a master regulator of cell immunity and inflammation. Appears as though Pfizer's scientific use of the word "supress" is accurate to me.
 
bradley said:
Yes it does. Whether the body's natural immune response completely recovers is another story entirely.

Enbrel binds to TNF alpha (with an extremely stable 100+ hour half-life) and profoundly inhibits its action as a master regulator of cell immunity and inflammation. Appears as though Pfizer's scientific use of the word "supress" is accurate to me.
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"End" seems to imply a much longer term, like permanent. Suppress however implies limited term. I think the definition posted of suppress is overbearing. /shrug
 
bradley said:
Yes it does. Whether the body's natural immune response completely recovers is another story entirely.

Enbrel binds to TNF alpha (with an extremely stable 100+ hour half-life) and profoundly inhibits its action as a master regulator of cell immunity and inflammation. Appears as though Pfizer's scientific use of the word "supress" is accurate to me.
Click to expand...

ending someone's immune system = super AIDS

people on enbrel do not have super aids. if they got super AIDS it would no longer be on the market
 
bradley said:
Yes it does. Whether the body's natural immune response completely recovers is another story entirely.

Enbrel binds to TNF alpha (with an extremely stable 100+ hour half-life) and profoundly inhibits its action as a master regulator of cell immunity and inflammation. Appears as though Pfizer's scientific use of the word "supress" is accurate to me.
Click to expand...

As an immunologist, let me tell you: your interpretation of what suppress means in this context is just wrong. If you were right, OP would be dead.

Suppression in immunity is a spectrum, it can be mild, moderate, severe, etc. Why don't people on Enbrel have live in a plastic bubble? Answer - it's a relatively mild suppressant. They don't give it to transplant patients, they need much stronger suppression for that (steroids and FK506, other stuff).
 
AreaCode707 said:
Still alive! Heading back tomorrow. Learned today that most Indians do not know how to swim.
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i learned a whole bunch of shit about indians after working with them for the past year.
if i made a thread on it, it would be instant-perma ban even though whatever i would be posting would be based entirely on facts and observations.
 
bradley said:
Life is too short to vacation in countries like India, Kenya, Bangladesh, Pakistan, and Syria etc over places like the US, Switzerland, Canada, Netherlands, Germany, Denmark, Sweden, Australia, Fiji, many of the Caribbean Islands etc.
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india was awesome, you have no idea what you're talking about.
 
Hanging in JFK Airport with NY-stye lox and bagel and tomato confit, apparently having survived the trip. One meal towards the end seems to have gotten to me a little bit but survivable. Good lord but I missed eating uncooked foods.
 
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