Per the specs posted at OCZ and TR, the Vendetta 2 is almost exactly conformable to the dimensions of the TRUE. One or the other has a different depth (width across the narrowest dimension of the fins), but I think it's a difference in order of magnitude similar to a half-inch.
Further, the base of the Vendetta seems symmetrical with the fins and pipes. Therefore, if -- as I -- you built motherboard ducts custom-fitted to your TRUE, you should be able to replace the TRUE with the Vendetta 2 without modding the ducts much at all. Further, the difference in "depth" shouldn't affect clearance with rear exhaust fans, if there was at least an inch's clearance to begin with.
Here's some advice for testing the Vendetta 2.
If possible, obtain and calibrate a digital thermometer such as you would find at Radio Shack. To calibrate it, wrap the sensor or transmitter in a zip-loc bag, and seal after pressing out as much of the air as possible. The bag should make contact with almost all of the surface area on the unit.
Bury the bag in a large bowl filled with ice-cubes, and add cold water. Wait a couple hours or more for the water and thermometer to equilibrate. Read the digital result. Use the difference of the result and 32F degrees to adjust your temperature readings with the thermometer.
When you test the cooler, make a note of the processor spec for posting here, and note the stock and over-clock speeds. You can test the cooler with stock settings alone, or test the cooler with both stock and overclock settings, but the stock settings are sufficient so that anyone can adjust to guesstimates of their overclocked thermal power wattage.
Use CORETEMP with the logging feature turned ON. Set the program to log temperatures every 8,000 milliseconds. This will record a reading every 8 seconds in your temperature log for each core.
Make a note of ROOM AMBIENT corrected for the thermometer reading before and after an hour's testing, or every so many minutes if you're inclined to that sort of anal-retentive accuracy. If your room temperature is fairly stable, the "before and after" approach should be sufficient.
Use PRIME95's multi-core "small-FFTs" torture-test, and test for a full hour of readings.
You can then close CORETEMP, access the log file with MS Notepad, and block-copy an hour's sample of load readings into another Notepad file so that you can save it and import it into MS Excel. From there, you can compute minimums, maximums, averages and standard error estimates, and you can make graphs showing the frequency distribution of temperature readings over a range from the minimum to the maximum temperatures as recorded in the log file. You should be able to compare the maximum and average values to published benchmark results if the processor TDP's are similar, after adjusting linearly for room-ambient.
This should prove or disprove the published benchtest results -- within some reasonable range of accuracy. If the processor TDPs between your test processor and that of the bench review are significantly different, you should have to adjust for the difference using the formula for thermal resistance. Even so, if you publish your results here and specify the TDP load-thermal-wattage of your processor with the results, it should be very useful to everyone else for decisions about migrating from the TRUE to the Vendetta 2.
By the way -- the earlier model Vendetta -- in review results -- is pretty much "blown away" by the TRUE in benchmark tests.