GagHalfrunt
Lifer
It's lame since it will probably mean less James Bond movies and the continuation of re-hashing. But if they could manage to make a separate, original spy series with a female lead, I could see that going well. Or simply adding a female 00# spy to the Bond universe.
That seems like a no-brainer. Introduce 008 or 009 or whomever as a protégé of Bond in an actual Bond movie and try to build up a following. Then spin her off into a new series with some crossover characters like M and Q. Nobody is going to accept a female James Bond any more than a female Batman. It's got to be a different character in the same universe.