The biggest issue that the desktop RR SKUs will face is potential disabling of memory overclocking. We just saw that with BR, and I wouldn't be surprised to see it happen on RR desktop. If they don't lock the memory bus, then, the next big issue will be package total power limits. It shouldn't be too difficult to provide sufficient cooling for the processor when there are solutions for the 1800X that can hold it at 4.0Ghz all around. So, provided that there is a way in the BIOS to allow the APU to run both the GPU and the CPU cores at max turbo for extended durations, and provided that the memory can be overclocked to work with with the premium low CL high Mhz memory modules, we could see desktop parts with easily 40-40% better graphics performance for enthusiasts.
Now, the flip side is, does any of that make sense? If you could afford to spend $100+ dollars MORE on high end memory AND another $50+ on a high end processor cooler, why wouldn't you just use a mid range Ryzen 5 and get a Radeon 560 4GB card? NewEgg has a 560 4GB card for $109 right now. No matter what you do to that APU, you aren't going to get that video performance up enough to make a huge difference in those benchmark scores, and especially without spending much more than the cost of that 560. The only place that any of this makes sense is in a mini-itx case for use in an entertainment center or in a very small desk situation. Someplace where you can't use even a low profile video card. Then, you'll run into the problem of how do you dissipate all the heat that a max turboed RR will pump out? That case will be tiny. The RR will easily be pushing 80+ watts when pushed to it's limits, if not more. I'm just not seeing it as a better solution than just getting a case that can hold a 560 or low profile card and making that work with a desktop Ryzen.
For business usage, a RR pro will be a big deal. It'll do a lot of things that businesses want, and I can see it being acceptable for even some higher end creative use that doesn't need bleeding edge video cards, but still needs acceleration to perform well enough.