ZOLPIDEM TARTRATE
Common Tradenames (See Complete Tradename Listing)
Ambien
Class
Nonbarbiturate Hypnotic
Dosage, Adult (usual)
Insomnia, Short-term use: immediate-release tablets, 10 mg ORALLY at bedtime
Insomnia, Short-term use: extended-release tablets, 12.5 mg ORALLY at bedtime
Dosage, Pediatric, (usual)
Safety and efficacy in children under the age of 18 has not been established
Dose Adjustments:
debilitated patients: 5 mg ORALLY at bedtime (immediate-release), 6.25 mg ORALLY at bedtime (extended-release)
geriatrics: 5 mg ORALLY at bedtime (immediate-release), 6.25 mg ORALLY at bedtime (extended-release)
liver disease: 5 mg ORALLY at bedtime (immediate-release), 6.25 mg ORALLY at bedtime (extended-release)
Administration
extended-release tablet: swallow whole; do not divide, crush, or chew tablet
How Supplied
Oral Tablet: 5 MG, 10 MG
Oral Tablet, Extended Release: 6.25 MG, 12.5 MG
Indications
FDA labeled indications
Insomnia, Short-term use
Contraindications
hypersensitivity to zolpidem products
Precautions
depressed patients
elderly or debilitated patients
hepatic or severe renal impairment
respiratory impairment
zolpidem has no anxiolytic properties, thus overuse is possible when used in anxious patients for sleep induction
Adverse Effects
COMMON
Gastrointestinal: Diarrhea, Nausea (7%), Xerostomia
Musculoskeletal: Myalgia (4%)
Neurologic: Dizziness (12%), Drugged state, Headache (19%), Somnolence (15%)
SERIOUS
Psychiatric: Depression, worsening, Suicidal thoughts
Drug Interactions
Bupropion (moderate, probable)
Desipramine (moderate, probable)
Ketoconazole (moderate, probable)
Rifampin (moderate, probable)
Sertraline (moderate, probable)
Venlafaxine (moderate, probable)
Pregnancy Category
Zolpidem: B
Breast Feeding
Zolpidem: Infant risk cannot be ruled out.