Alzheimers vaccine works in mice!

[techs]

http://health.yahoo.com/news/173545

Alzheimer's vaccine works on mice: Japan scientist
March 28, 2007 11:49:28 PM PST

Japanese scientists have developed an oral vaccine for Alzheimer's disease that has proven effective and safe in mice, the director of a research institute behind the project said on Thursday.

The team is preparing to move to small-scale clinical trials in humans, possibly this year, said Takeshi Tabira, director of the National Institute for Longevity Sciences in Aichi, central Japan.



Wow. this really looks like breakthru!

 

[FilmCamera]

"Breakthrough"

 

[Minerva]

Sure sounds like a wonder drug. Hopefully it won't cost $300k per gram.

 

[AnyMal]

Huge breakthru?

Sure, if you find a way to convert people to mice.

 

[Ausm]

I hope it works that well on humans.


Ausm

 

[eleison]

Yea, my $50 contribution last year helped!!!

 

[AbAbber2k]

Originally posted by: AnyMal

Huge breakthru?

Sure, if you find a way to convert people to mice.

Have there been other Alzheimer's drug tests that were successful on mice? If not then I would call this a pretty big breakthrough.

 

[edmicman]

I can't wait until Big Pharm gets their hands on this!

 

[Queasy]

Originally posted by: AnyMal

Huge breakthru?

Sure, if you find a way to convert people to mice.

Well, scientist did create a sheep that is 15% human.

Seriously, as someone who has watched Alzheimer's destroy relatives on both sides of my family and is wondering when and if it'll happen to my parents....any news like this is good news.

 

[theeedude]

Elderly mice everywhere rejoice. 😉

 

[Feldenak]

Originally posted by: Queasy

Originally posted by: AnyMal

Huge breakthru?

Sure, if you find a way to convert people to mice.

Well, scientist did create a sheep that is 15% human.

Seriously, as someone who has watched Alzheimer's destroy relatives on both sides of my family and is wondering when and if it'll happen to my parents....any news like this is good news.

Agreed.

 

[Luthien]

I want to try some right now.

 

[Luthien]

Originally posted by: Feldenak

Originally posted by: Queasy

Originally posted by: AnyMal

Huge breakthru?

Sure, if you find a way to convert people to mice.

Well, scientist did create a sheep that is 15% human.

Seriously, as someone who has watched Alzheimer's destroy relatives on both sides of my family and is wondering when and if it'll happen to my parents....any news like this is good news.

Agreed.[/q

Wow, this gives sheep shagging some legitimacy 🙂

 

[Triforceofcourage]

Mice everywhere rejoice except for the poor one residing in a server room 🙁

 

[ElFenix]

not really a vaccine, but a very clever way to cause the body to defend itself. very neat.

 

[LegendKiller]

Originally posted by: AnyMal

Huge breakthru?

Sure, if you find a way to convert people to mice.

I may be corrected here but let me take a stab at this.


When you are young your body produces certain anti-proteins that can break down Amyloid proteins in your brain. As you get older your system stops producing these protein breakers. Your body, in a secondary reaction, concentrates Amyloid proteins into clumps. These clumps inhibit the firing of neurons in the brain, causing loss of functioning, but with the general ability to "save" the body. As these clumps become more dense they inhibit more functioning. This is why you get the "regression" often seen in Alzheimers patients. As more parts of your brain are inhibited, such as your memory areas, you lose functions and actual memories.

The ability to break down the Amyloids, before they form these clumps, is essential. If the body can be "rallied" and the system be better enabled to fight and break down the Amyloids, Alzheimers can be permenantly staved off.

Now, from what I understand, Amyloid proteins have the same structure whether they are in rats or humans, since the basic chemical make-up is the same. Thus, if you can find a way to keep the immune system functioning and pumping out anti-Amyloid chemicals, you can transport that treatment to any Amyloid inflicted animal.

The question becomes, are at anti-Amyloid systems the same as Humans and will the side-effects (if any) be the same or more (or less) harmful?

Either way, this is a massive breakthrough, and one that can affect not just Alzheimers.

One question I have though, if this does work on Humans, will it work retroactively? Will we see Alzheimer patients get better, or is this just a preventative medicine?

 

[SVT Cobra]

Weird but I swear this happened a year ago. Maybe a different drug.

 

[moshquerade]

sure, they can think again, but when are they going to make it so they can see?

 

[FlashG]

Originally posted by: moshquerade
sure, they can think again, but when are they going to make it so they can see?

like in 3 blind mice?? what

 

[dmcowen674]

Any bets in Vegas yet that we'll never see it?

 

[everman]

Mice invent all the good vaccines for themselves.

 

[flunky nassau]

Very cool. Hopefully these clinical trials in humans will show that improvement in the signs of Alzheimers also translates into improved symptoms.

 

[potato28]

Yay! Maybe now I'll... Hi my name is potato28! :beer: all around! 😀

 

[BunLengthHotDog]

Human testing is typically where they find issues with these types of new treatments. Quite a few (not specifically alzheimers) animal trials have looked very promising only to fail miserably when tested on humans.

Obviously one can dream that isnt the case here, but I wouldn't get my hopes up too high.

 

[BurnItDwn]

I have high hopes and low expectations.
That way I won't be disappointed!

I have informed my 40 something co workers (I'm in my 20s) this news, and told them that there is still hope for them. One of them showed gratitude, the other guy left for the day, so I'll get his reaction tomorrow.