Any S939 board should run perfectly in single channel.... you'll see roughly a 5% performance hit in most instances so it's not too bad. Whether you can utilize 3 DIMM's depends on the board in question, some will handle it, whereas others won't. If you do use 3 DIMM's it'll be forced to run in single channel though.
You'll need 2 or 4 DIMM's for DualChannel operation.