These are some of the projects going on at one of the supercompting centers on my campus. Most all of these are run on some sort of linux or open mosix cluster,
Fast Heuristics for Very-Large-Scale Maximum Independent Set &Related Problems Using Neural Networks Approach
An Efficient Approach for Solving the Assignment Problem with Side Constraints
Greedy Solutions of Selection and Ordering Problems
Insights Into Two Solution Procedures for the Single Machine Tardiness Problem
Geometric structures and stabilities of CuSin clusters (n=8,10, 12)
Computational Studies on Si7 Clusters Deposited on a Graphite Substrate
etc............