If I didn't have kids, I'd love a micro home. I went through a minimalist phase where I digitized all my crap (books, paperwork, movies, music, photos, etc.) and it was really nice to have the freedom of not having "stuff" everywhere. You could set it up really slick by having an AIO computer like a big-screen iMac & a large flat-screen TV or projector with like a Roku player so that all of your digital life stuff is accessible. Throw in a Casper bed in a Murphy wallbed frame for spacesaving & suddenly you have a lot of room available in a small footprint. I've seen combo washers/dryers that go next to your dishwasher too, so you can really have everything compact if you make wise decisions & invest up front:
http://tinyhousetalk.com/top-5-washer-dryer-combos-for-tiny-houses/
Part of the problem though is if you have hobbies. Like, my road bike is pretty minimal - it's a skinny frame with a small toolkit & a couple spare parts. But I also have food allergies & cook the bulk of my food at home, so I have a good 30 appliances, which takes up a lot of storage space. So if you like to do anything that requires tools & supplies, from cooking to woodworking to whatever, the smaller space can be really difficult. If you're say more outdoor-oriented & like to do things like hiking or running that don't really require a lot of gear, then you can get away with packing light.
I agree about untouched rooms. My concept for a home would be an open-concept kitchen/family room for the main living space, since I'm either doing food stuff or TV/computer stuff most of the time, and some living quarters & storage space and maybe a home theater room off to the side. I don't think there's anything wrong with having like a 4,000-square-foot home, but for my needs, 2,000 would probably be overkill.
I have a buddy who is really into the towable micro homes; I recently saw one parked at McDonalds, it was really cool - an entire mini wood home on a trailer. But if you think about it...why not just buy an RV? Tiny homes can cost anywhere from $15k to $80k - you could get a pretty nice used Winnebago for that (and help save the environment if you choose to go used by not letting it go into a dump), which already has all of the work done, hookups for campgrounds for water, power, and sewer, optionally a motor coach so you don't need a separate truck to pull it around, etc.
I have seen some people do tiny homes with kids, although that gets difficult number one for their equipment (toys, diapers, etc.) and number two if you live in a location like the northeast where it snows & they can only play outside in the cold for so long, then you have to bring them in & then they get cabin fever from being in such a small space. But I think for like a single person or a young married couple, it'd be awesome. There was an article awhile ago about the push for smaller apartments in places like NYC, where the rent would be cheaper & for people who liked the city life more than staying at home, it'd be more of a place to crash than anything - eat food out, do laundry at a shared facility, hobbies are all socially-oriented, etc.
It's a neat idea for sure.