Usually aero (desktop composition, the graphics hardware accelerated bit) is disabled when the user runs a game. For old games I tend to switch off desktop composition in the shortcut's compatibility settings just to play on the safe side.
This was true in Vista, in 7, none of my games disable aero unless specifically told to do so in the compatibility tab... I know this to be true because my 2nd monitor still has all the translucency enabled when I launch a game.