First find out WHAT RAID 0 IS...look at the FAQ(Frequently asked questions)
Basically, after you read that you will know that two identical drives are required. The interface basically sends half of the data to each HD, making things go quicker(HDs don't have to deal with ALL the data.
As for the interface, you will need a RAID controller. If you are building a new system(YOu are) get a motherboard with RAID. it will have two IDE-like conectors. You plug in the two drives on different channels, and turn it on. THen you will see a bios that coressponds to the RAID controller. Go into the meny(usually press "Control + A "or "+R" and set the RAID config up. it is very simple. Basically from then on, as long as you use the supplied drivers, it will look like a drive equivalent to the storage capacity of both and with a greater speed than a single drive(not double the speed however). Remember though, if one of the drivers physically fails, you lose ALL your DATA, not JUST HALF. ALso, it is a pain in the butt to install any windows OPerating system besides win2k or XP..i.e WIn95 or 98 are out of the question for simplicity's sake.
ALso, watch out with buring 12x media at 16x. The disks go grazy, shoot out of the case, and have been know to kill on ocassion.