It all depends on times scale and precision you want to achieve. Generally speaking you can model orbits of 100-200 bodies on a modern computer within reasonable time and with ok accuracy. By modeling I mean that you calculate 2 body interaction of all possible pairs at each step. But here is the trick there is no need to calculate influence of all planets, moons , asteroids on each other. For example what is the influence of all asteroids in the asteroid belt on earth orbit? The answer is almost 0 Why ? because it is said on wikipedia that : "The total mass of the Asteroid belt is estimated to be 3.0-3.6×1021 kilograms, which is 4% of the Earth's Moon. Of that total mass, one-third is accounted for by Ceres alone." Not only this the asteroid belt contains thousands of bodies that means that Earth can not "see" individual asteroid in this mess. BUT if you want to calculate an orbit for say millions of year with 10 miles precision you have to calculate earth-asteroid interaction exactly which is impossible afaik. On long time scales even bigger problems occur, you have to take into account such things as tidal waves, relativistic effects and even decrease in solar mass due to radiation. In practice what you need to do is take say Neptune and Earth , write down gravitational force for them , look how much they would pull each other on time scales that you want to consider and then decide if this distance is interesting for you or it is too small to take into account. You should do this estimates for all bodies and effects you think are important. At the end of the day I bet you will discover that you want to calculate interactions of only big planets and calculate trajectories of asteroids moving in the gravitational field of these planets.
About galaxy (I am not an expert in astrophysics so what I am going to say might be half true) No sane astrophysicist would calculate motion of individual stars in the milky way just because there are 200 billion stars there. What most of them do i think threating the problem as fluid dynamics. That is breaking up galaxy into cubes with say 10 light years across, then they calculate density of matter inside such cells and finally trajectories of these cells. It is probably doable on a modern computer if you take cell of size 1000 ly then the problem becomes 2d because the thikness of milky way is about 1k ly. You can estimate radial distribution of stars in the galaxy. BUT here is the problem: you can not apply Newton's law to this system, the most obvious reason is that gravitational field propagates with the speed of light so it would take 1000 year for gravity to travel just through your elemental cell. As you can see problem is not in calculations but learning all this astrophysics stuff (i am not an astrophysicist and have little idea on where to start).
If you want to model something the most interesting part is figuring out what is important and learning new stuff. After this it is an exercise in programming.