I don't plan to ever go back to 250w TDP GPUs, unless there is a really really compelling reason. This one uses 1.4x the electricity, for 1.4x the performance, so to me it's just more sensible to add another lower performing, lower priced card. As for running multiple instances of F@H, I believe my 1070/1080 were close to 100% of the power of the card, so unless the Ti isn't as fully utilized, I don't see any benefit to multiple instances.