TheWart, BennyD are both right while the frequencies coming from the sub are non-directional placing the sub in different parts of the room will alter the sound. The room and location you place your speakers will change the sound not so much for sats., but for full size speakers and subs.
For my Z560's I placed my sub under my desk with the port firing into open air and driver facing the outer room, prolly not the most neutral location but the most practical for my situation. I wouldn?t but the sub in a corner, bass would be far to exaggerated. I would also take note of where the driver and port are firing, into open air would be best. If possible I would try to put the sub in open area of the room not near any walls or large objects.