Sorry if this has already been a thread before.
Anyway, here's mine in no particular order
Sadler in RE4
Mundus in DMC (particularly his 1st form)
Virgil in DMC3
Jafar in Disney's Aladdin for the Super NES (the final boss in the Genesis/DOS version is what kills that otherwise superior version)
The Dahaka in PoPWW
The 2 final bosses (the Prince's alter ego and the other one) in Two Thrones
Ganondorf in WindWaker even though I can beat him without getting hit
Ganon and Ganondorf in Ocarina of Time
Dracula/Death in Portrait of Ruin
Dracula in Order of Ecclesia
Walter and Death in Lament of Innocence
Dracula in Curse of Darkness
Dracula in Rondo of Blood (original and Chronicles)
Mike Tyson's immortal ass (can't beat him) in Mike Tyson's Punch-Out
The long-haired horned guy (and keeping the gate up) in the Revenge of Shinobi.
The last boss in Shadows of the Empire (so long ago I don't remember the name)
Razorbeard in Rayman 2.
Mr. Dark in Rayman.
Anyway, here's mine in no particular order
Sadler in RE4
Mundus in DMC (particularly his 1st form)
Virgil in DMC3
Jafar in Disney's Aladdin for the Super NES (the final boss in the Genesis/DOS version is what kills that otherwise superior version)
The Dahaka in PoPWW
The 2 final bosses (the Prince's alter ego and the other one) in Two Thrones
Ganondorf in WindWaker even though I can beat him without getting hit
Ganon and Ganondorf in Ocarina of Time
Dracula/Death in Portrait of Ruin
Dracula in Order of Ecclesia
Walter and Death in Lament of Innocence
Dracula in Curse of Darkness
Dracula in Rondo of Blood (original and Chronicles)
Mike Tyson's immortal ass (can't beat him) in Mike Tyson's Punch-Out
The long-haired horned guy (and keeping the gate up) in the Revenge of Shinobi.
The last boss in Shadows of the Empire (so long ago I don't remember the name)
Razorbeard in Rayman 2.
Mr. Dark in Rayman.