There is a Windows port of this game. It's a bit buggy - sometimes the audio just turns itself on, and you have to toggle it a few times before it shuts up.
Blue Lasers + Homing missles are the best combo. The spread fire is pretty good too, but just get up close to the bosses.
Can't believe this game actually lags my computer in some areas!
Or the pink plasma weapon + dumbfire missiles. The dumfire things pack a hell of a punch.
Or if you just want to wipe out targets right in front of you, laser + dumbfire.
Homing + standard weapon = very little maneuvering. You get almost full screen weapons coverage. It's weak, but so are most of the enemies.
For a bomb, I prefer that cluster bomb. It has the nice bonus of acting as a shield.