If I were you I'd just drain twice as often and not bother with the block. In the case of both of my cars you need to be almost god-like to get to the block and unscrew both bolts and then actually screw them up again. I bet nissan has a special tool to do it. It's so obscure as to be silly. I just drain the rad, fill it up, and be done with it. You only change out half the coolant each time, but it's a LOT easier.
Or, as mentioned, you could use a flush kit and flush it all with hose water if you want. Then if you were anal you could run distilled through it just to remove hose water deposits,t hen fill up with your coolant mix.