This actually made me think a bit.
Mute.
-It sucks donkey ass not to see. I would dearly miss looking at my fiancee, friends, family, and the wonders of the world. Being blind is the worst without a doubt.
-I would cry not hearing the voice of my future kids, my dear fiancee, joys of music, watching TV/movies, the waves crashing, birds chirping, all the wonderful sounds the world offers.
-Being paralyzed is just downright stupid. You can't travel, have sex, have fun, just stuck to the bed until you die. I'm not the most active guy, fiancee and I LOVE doing activities.
-I'm a very vocal guy, love long talks with friends over drinks, love public speaking etc, but lot of that can be mitigated by electronic communication and writing. And there's ZERO hindrance when watching a movie, listening to music, hearing my friends and family, going rock climbing, swimming, etc.
Being mute, easily.