Bad things happen when you don't have the correct heat range. Just recently, I went to replace the NGK plugs on my bike, but couldn't find any. So, I had to settle with Champions, which were cross-referenced from the NGK's. Let's just say that cross referencing on spark plugs DOES NOT WORK!
Typically, I use +1 heat range plugs (+1 from stock) and they work great during the cooler months. But, the Champions were like +2. Let's just say, I was cruising along one day and the engine started balking and died on me. I was finally able to get the engine to start and made it home. Once I got home, I pulled the carbs (I thought maybe a diaphragm popped loose or a main-jet fell out) and found them to be alright. Then, I remembered the Champions that I put in the week before. Sure enough, the center electrode on one plug was completely melted off and stuck to the side electrode. Then, on another plug, the center electrode showed signs of overheating. Pre-ignition sucks! Now that I have +1 NGK's back in the bike, she's running great.