I fly into Midway on Thursday then drive two hours into Indiana
Am I going to survive:
Note, i'm from Texas and have NEVER driven anywhere NEAR snow.
If you do encounter snow, it really isn't
that bad to drive in. The most important thing is to keep your cool (no pun intended). That's important because I would assume that people that tend to freak out are more likely to cause or be in an accident. Anyway, similar to rain, snow is just another thing that reduces the friction between your tires and the road. So, you just follow some of the same rules: increase distance between vehicles, consider the increased stopping distances, and avoid jerky movements. In regard to the latter, sticking to slow and steady movements helps to avoid "upsetting" the balance of your car that could throw it into a spin.
One thing that snow tends to see more often is persistent accumulation. One aspect that is usually ignored in regard to accumulation is the snow that sticks on multi-lane roads between the lanes. If the lane that you're driving in is fairly clear but there's crud in between lanes, be careful if you need to change lanes. Do it slowly.