I usually don't run anything on my machine. All the start up items from my system config are far and few between i.e. scanregistry, systemtray, loadpowerprofile, vshwin32exe, vsstatexe, vsecomrexe, vshwin32exe and that is it.
I've searched the web and so far can't come up with a reason why winME is using so much physical memory. I guess I could down load cacheman or an after market memory reclaimer but really don't want to.