If you havent picked your cloning software yet, I HIGHLY reco PowerQuest Depoly Center. I am upgrading 30 new rigs @ work (XP PRO) and deploy center has a built in Sysyprep utlity that will walk you thru your answer files and set the up autonaticially for you. VERY NICE feature.
Since my rigs all came with OS as OEM, I left it blank for the key, put in the domain as a workgroup so I could add to domain later, let it specify computer name and had it answer for desktop size, timezone, resolution etc. All I really have to do is re enter the license key, approve the EULA for the basic setup. Then I do what I have to do, rename computer and join it to the domain. It is a VERY nice wizard like tool that creates the answer files for you. ANd yes, it even does NTFS partitions. I was able to deploy my 1st 6 rigs within 1 week using it. That includes getting the rigs on monday (they were supposed to be win 2k, but they shipped XP instead and I decided to keep it so took some time to adjust for that), configured users desktop settings like their replaced rigs(shortcuts, etc) and even imported all their email and stuff.
Good stuff!