Yes, you may use the 32bit modules by their lonesome rather than using them in pairs like traditional 16bit RD modules. However, you must still must use a CRIMM, that's no problem though. On another note, the 32bit modules have a lower latency (not sure of the exact number, probably 34-40ns) rating and theoretically can be clocked higher, there are however 32ns 16bit Samsung Original modules that may be purchased from Mushkin. They are only 128mb though.