I agree with these guys...either the E8400 or the Q6600.
I debated with myself for the last two months and decided with the Q6600. It got it for $199 at Microcenter last week. I like the future proofing and the price point of the quad...and didn't want to pay the price premium for the 45 nm quad.
The multi-tasking ability of the stock Q6600 is pretty impressive. I have built about 7 Core 2 systems for myself and friends over the last year and have overclocked the E6400, E6600, and a few of the B3 Q6600s. And recently...I have ordered 3 Dell boxes with the Q6600 for customer workstations...both with XP Pro and Vista Business.
The multitasking ability of the Dell systems (Q6600) compared to the 6750 or 6550 is pretty obvious and keeps customers happy...add in the 80gb raptor hd option for $70 and the systems fly.
HTH.