Side button placement in general is hit and miss for each person as everyone's hand is slightly different. With most mice, it seems the front is a tad tall too tall so my ring finger is draped over the side and exerts some pressure on the side, an unfortunate design if there were side buttons on the right side of my mouse. Perhaps if mice were narrower, it wouldn't be as much of a problem. But then again, a person with larger hands may feel the need to pinch the mouse in order to move it sideways, causing unnecessary clicks of a right-side button.
I remember seeing a mouse with 4+5 in 2 different possible arrangements on the left side to accommodate those with slightly larger/smaller hands and thought that was cool. What they need is a fully customizable mouse with rails so you can finely adjust the position of buttons, including whichever side you prefer.