You can see what I'm talking about in the second photo of this Cooler Master case review:
http://anandtech.com/show/9560/the-cooler-master-mastercase-5-review
With a front to back airflow plan, this seems like it would allow air to leak in from the back panel straight into the rear fan, short circuiting the front to back airflow effectiveness. Even with a different airflow plan, I can't see that this opening would ever be helpful as the airflow from the perforated grill to the rear fan doesn't seem to go over any components, except slightly the rear tops of the PCIe cards.
http://anandtech.com/show/9560/the-cooler-master-mastercase-5-review
With a front to back airflow plan, this seems like it would allow air to leak in from the back panel straight into the rear fan, short circuiting the front to back airflow effectiveness. Even with a different airflow plan, I can't see that this opening would ever be helpful as the airflow from the perforated grill to the rear fan doesn't seem to go over any components, except slightly the rear tops of the PCIe cards.