Me too. Had one get hosed around maybe '05 or '06, went to NTFS, and it's mostly been good since. There should be no difference between an HDD and thumb drive, so long as the controller doesn't go haywire if unplugged while writing.
USB 2.0 on the PC side, with whatever drivers were in the kernel. I had meant to use USB 3.0, but Dell makes all the ports black, so I ended up using the wrong one.
There are also differences at times when using front of case ports and back motherboard ports.
A lot of case manufactures use low quality/gauge or unshielded wire and this can cause USB devices to be slow.
