I upgraded to an optical USB mouse a few months ago and it's really nice, but now my mobo's USB ports are all full - mouse, printer, scanner, & webcam - and I don't really want to pick up a hub yet.
So it looks like I gotta slap that USB->PS2 adapter onto my mouse if I pick up another USB device...
Also, it seems like the USB mouse occasionally stutters when my CPU and hard drive are under maximum load... I don't remember my old PS2 mouse doing that.