Interestingly enough, I'm contemplating this exact thing. I have the Shuttle AK35GTR and a SBLive XGamer 5.1 I currently am using. Unfortunately, I occasionally get a BSOD with an "IRQ not less or equal to blahblahblah" which can be traced directly to the damn SBLive card. :| I've tried changing the PCI slot that the card is in...but W2K gives everything an IRQ of 11, so I'm screwed anyway, actually.
I'm thinking about trying the onboard sound and burning the card. I would imagine that as long as you have a decent set of speakers, the sound quality shouldn't be much different. I am concerned about "fixing one problem and creating another" though. Except for my old Dell *snicker* I've never used onboard sound, but am considering it now.