The single isa slot and the lowest pci slot are probably shared, like many other mobos. The plate on an isa card is angled up, and on a pci card it is angled down. you may use one or the other to occupy the opening in the case, but not both. For the money, the Antec sx830 and sx1030 are hard to beat for cooling and expansion, not to mention the killer pp303x athlon approved power supply.