I think Steve Carell can be hilarious, but all he's done thus far (that I have seen anyway) is comedy, even though his role was semi-serious in Little Miss Sunshine. I think he'd make a great antagonist. Not as an evil plotting bad guy, but maybe a guy that either is or goes nuts, snaps, and shoots up a Wal-Mart or is a serial killer or something. Maybe even something like One Hour Photo. I thought that sucked because Robin Williams shouldn't stretch himself, IMO, and the latter half of it just wasn't a good movie anyway. But Steve Carell as an oppressed character pushed past his limit would work well, I think.
Who else?
Who else?