I think it should just work on the stuff that utilizes it (there's 3 toggle switches for Stream HDR videos, Play HDR games and apps, and Use WCG apps), but there's other aspects that could influence things. I tried a UHDTV as a monitor for a bit, and enabling HDR on Windows forced colorspace into 4:2:2 (or maybe even 4:2:0) which screwed up even desktop color profile.