Are you talking about the color profile setting in windows? After running the calibration, spyder3 generates its own profile to replace whatever was there.
If your monitor has a 'sRGB' mode, don't bother with it. Unless you have a high-end self calibrating monitor, it will only make some assumptions and set it to what it thinks is the correct sRGB profile. A correct profile accounts for the ambient lighting in the room as well as other effects like monitor aging, and a preset mode cannot compete with what spyder3 does. In fact, in the sRGB mode, you're likely to lock out certain settings which you'll need to adjust during the calibration process making the whole thing a lot more difficult.
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