When the printer shows the ink as almost gone. One of the reasons I went with the HP PhotoSmart 3210 (other than the descending numbers of easy remembering of the name!) was the fact that it has all the colors split apart. I hated throwing away cartridges with ink left in some of the compartments because one color was dead.
Not until I can actually see the print is degregated. The computer telling me to change it many times wastes a lot of ink. But now we have a color laser since they are so cheap.
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