Do you have a specific requirement for RAID? Honestly, I would just run them singly as volumes by themselves. With four drives of two different sizes, you could do RAID 5 of 4 80gb drives, but you would also have to buy a RAID controller for it to get any decent performance. RAID 5 on a mobo will result in a performance hit. Or you could do a seperate RAID 1 and RAID 0 array, but I wouldn't do it if you dont' need to.