What settings to get the best out of audio?

[fustercluck]

I got an Audigy 2 ZS, and some nice headphones, but i want to make sure i'm getting the best out of both of them. There are lots of different settings and stuff...what can i do to make sure I'm getting the best out of my audio?

 

[fustercluck]

So many options have me confused =x, can anyone help out?