Well, it depends on the game. I can run pretty much any game i know (save far cry and FEAR) on 12x10 because of my lack of ram. Those two games get too stuttery on that resolution. But like HL2, runs great on 12x10, but my 512 ram only lets me play it at medium settings
oh, and no AA/AF for me. Just cuts down performance and I really don't pay much attention to it. Never used it before (lack of good hardware) and really see no need to.