you shouldn't need to delete any folder from the registry. when i instal my old harddrive onto a new mobo, all i did was doing a 'hdd drive detection' in the bios, then save the new bio setting and reboot.. after your computer reboots, windows will look for all the necessary driver to install during the startup.. if windows can't find the driver it needs for the hardware, it will tell you then you have to manually install them..
if i were you, i would make sure that i have all the hardare drivers ready in c drive(put them in a folder/directory). if by any chance windows can't find the appropriate hardware driver after you installed the hdd on the new mobo, you can install the missing driver during the window startup.